The dynamic instability of actin filament barbed ends
نویسندگان
چکیده
منابع مشابه
Regulators of actin filament barbed ends at a glance.
Cells respond to external stimuli by rapidly remodeling their actin cytoskeleton. At the heart of this function lies the intricately controlled regulation of individual filaments. The barbed end of an actin filament is the hotspot for the majority of the biochemical reactions that control filament assembly. Assays performed in bulk solution and with single filaments have enabled characterizatio...
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Cell motility and actin homeostasis depend on the control of polarized growth of actin filaments. Profilin, an abundant regulator of actin dynamics, supports filament assembly at barbed ends by binding G-actin. Here, we demonstrate how, by binding and destabilizing filament barbed ends at physiological concentrations, profilin also controls motility, cell migration, and actin homeostasis. Profi...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2021
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.202102020